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An error occurred while trying to access the requested resource

Citrix WebInterface 5.3 on IIS7

While configuring a Citrix NetScaler 9.2 in conjunction with WebInterface 5.3 I received the following error message when executing a published application.

An error occurred while trying to access the requested resource.

I thought to myself….no problemo, since I blogged about this problem before (source). This solution didn’t help. After changing the RequireLaunchReference value I still receive the error while opening an application. The only difference is that the event viewer message isn’t generated anymore.

After searching the internet I found another Citrix knowledge base article, called “Application Launch Failure in Web Interface 5.0 through 5.3”. This article provided me with the solution.

It looks like IIS 7 differs quite a lot from earlier versions. Citrix’s background on the problem:

It is currently suggested not to run .NET 1.1 or .NET 4.0 on a windows 2008 Web Interface server that is using Web interface 5.0 through 5.3. The .Net Framework 2.0 common language runtimes will be used in conjunction with the 3.0 and 3.5.

Don’t ask me what it is, because I don’t know. Switches, routers, firewall and other networking components don’t use Microsoft .NET…..